The diet with high levels of fructose, sucrose
Scientists at Cincinnati Children’s Hospital Medical Center have discovered that a diet with high levels of fructose, sucrose, and of trans-fats not only increases obesity, but also leads to significant fatty liver disease with scar tissue.
The study, which was conducted with scientists from the Metabolic Disease Institute at the University of Cincinnati, is published online Wednesday in the journal Hepatology.
The study was conducted in mice, some of which were fed a normal diet of rodent chow and some a 16-week diet of fructose and sucrose-enriched drinking water and trans-fat solids. Their liver tissue was then analyzed for fat content, scar tissue formation ( fibrosis), and the biological mechanism of damage.
This was done by measuring reactive oxygen stress, inflammatory cell type and plasma levels of oxidative stress markers, which are known to play important roles in the development of obesity-related liver disease and its progression to end-stage liver disease.
The investigators found that mice fed the normal calorie chow diet remained lean and did not have fatty liver disease. Mice fed high calorie diets (trans-fat alone or a combination of trans-fat and high fructose) became obese and had fatty liver disease.
“Interestingly, it was only the group fed the combination of trans-fat and high fructose which developed the advanced fatty liver disease which had fibrosis,” says Rohit Kohli, the study’s main author. “This same group also had increased oxidative stress in the liver, increased inflammatory cells, and increased levels of plasma oxidative stress markers.”
Kohli said Fructose consumption accounts for approximately 10.2 percent of calories in the average diet in the United States and has been linked to many health problems, including obesity, cardiovascular disease and liver disease. He hopes to further investigate the mechanism of liver injury caused by high fructose and sucrose enriched drinking water and study a therapeutic intervention of antioxidant supplementation.
Antioxidants are natural defenses against oxidative stress and may reverse or protect against advanced liver damage.
Category: VOICE to HEALTH



